Description

Cytochrome P450 14A-Demethylase Inhibitor 1K is a potent and selective small-molecule inhibitor targeting the CYP51 enzyme, a key component in sterol biosynthesis. This compound is of significant value for biochemical research and drug discovery, particularly in the study of fungal infections and cholesterol metabolism pathways. It is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies engaged in developing novel antifungal agents or investigating sterol-related metabolic disorders.

Application

• Biochemical Research: Used as a critical tool compound to study the function and inhibition of the cytochrome P450 14α-demethylase (CYP51) enzyme in vitro.
• Antifungal Drug Discovery: Serves as a lead compound or reference standard in the development of new antifungal therapeutics targeting ergosterol synthesis in pathogenic fungi.
• Mechanism of Action Studies: Employed to elucidate the sterol biosynthesis pathway and validate targets in parasitology and mycology research.
• High-Throughput Screening (HTS): Utilized as a control or reference inhibitor in assay development and screening campaigns for CYP51 activity.
• Enzyme Kinetics: Applied in detailed kinetic studies to determine IC50, Ki, and other pharmacological parameters for CYP51 inhibition.
• Chemical Biology Probes: Can be used to develop chemical probes for understanding sterol metabolism in various biological systems.

Basic Information

Product Name	Cytochrome P450 14A-Demethylase Inhibitor 1K
CAS No.	1155361-09-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CYP51 Inhibitor 1K; 14α-Demethylase Inhibitor 1K; CYP450 14DM Inhibitor; Sterol 14α-demethylase inhibitor; Lanosterol 14α-demethylase inhibitor; Antifungal research compound 1155361-09-3; Research inhibitor for ergosterol synthesis
EINECS	Contact for details

Quality Control

Our Cytochrome P450 14A-Demethylase Inhibitor 1K is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. Consider storing under inert atmosphere for long-term preservation of stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.