Description

Cytochrome P450 14A-Demethylase Inhibitor 1J is a potent and selective small-molecule inhibitor targeting the CYP51 enzyme, a key component in the sterol biosynthesis pathway. This compound is a critical research tool for studying fungal and protozoan infections, as well as cholesterol metabolism, due to its specific inhibition of the 14α-demethylation step. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in antifungal drug discovery, parasitology, and metabolic pathway analysis.

Application

• Antifungal Agent Research: A key reference standard and lead compound in the development of novel antifungal drugs targeting ergosterol biosynthesis in pathogenic fungi like Candida and Aspergillus.
• Parasitology Studies: Used to investigate treatments for protozoan infections (e.g., Chagas disease, leishmaniasis) by inhibiting sterol synthesis in parasites such as Trypanosoma cruzi.
• Biochemical Pathway Analysis: Serves as a precise tool to dissect and validate the cytochrome P450-mediated sterol demethylation pathway in various biological systems.
• Enzyme Inhibition Profiling: Employed in high-throughput screening (HTS) and enzymatic assays to evaluate selectivity and potency against CYP51 isoforms.
• Veterinary Medicine Development: Investigated for potential applications in treating fungal infections in animals.
• Agricultural Fungicide Research: Explored as a model compound for developing new agrochemicals to combat crop diseases caused by fungi.

Basic Information

Product Name	Cytochrome P450 14A-Demethylase Inhibitor 1J
CAS No.	1155361-08-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CYP51 Inhibitor 1J; 14α-Demethylase Inhibitor 1J; Sterol 14α-Demethylase Inhibitor; Lanosterol 14α-Demethylase Inhibitor; Antifungal Research Compound 1J; CAS 1155361-08-2; P450DM Inhibitor 1J
EINECS	Contact for details

Quality Control

Our Cytochrome P450 14A-Demethylase Inhibitor 1J is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.