Description

Cytochrome P450 14A-Demethylase Inhibitor 1G is a potent and selective small-molecule inhibitor designed to target the CYP51 enzyme, also known as lanosterol 14α-demethylase. This compound is critical for disrupting the biosynthesis of ergosterol in fungi and other sterols in specific metabolic pathways, making it a valuable tool for research and development. It is primarily utilized by pharmaceutical researchers, biochemists, and agrochemical scientists investigating antifungal mechanisms, novel therapeutic agents, and sterol metabolism. The high specificity of this inhibitor makes it essential for in vitro and in vivo studies focused on enzyme function and pathway validation.

Application

• Antifungal Research & Development: A key biochemical tool for studying the mechanism of action of azole and other antifungal drug candidates by inhibiting the CYP51 enzyme.
• Pharmaceutical Discovery: Used in high-throughput screening (HTS) and target validation assays to identify and optimize new therapeutic agents targeting sterol biosynthesis.
• Biochemical Pathway Analysis: Essential for elucidating the sterol biosynthesis pathway in fungi, parasites, and other organisms in academic and industrial research settings.
• Agrochemical Development: Investigated for potential applications in developing novel fungicides for crop protection by targeting plant pathogens.
• Enzyme Kinetics & Inhibition Studies: Serves as a reference standard for determining IC50 values, binding affinity, and inhibition constants in enzymatic studies.
• Veterinary Medicine Research: Applied in research for antifungal treatments in animals, targeting pathogens that affect livestock and companion animals.

Basic Information

Product Name	Cytochrome P450 14A-Demethylase Inhibitor 1G
CAS No.	1155361-05-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CYP51 Inhibitor 1G; Lanosterol 14-alpha Demethylase Inhibitor 1G; CYP450 14DM Inhibitor; Sterol 14α-Demethylase Inhibitor; Antifungal Research Compound 1155361-05-9; P450 Inhibitor 1G; Ergosterol Biosynthesis Inhibitor
EINECS	Contact for details

Quality Control

Our Cytochrome P450 14A-Demethylase Inhibitor 1G is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to meet high-grade research standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and assay results is provided with every shipment to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.