Description

Cytochrome P450 14A-Demethylase Inhibitor 1D is a potent and selective small molecule inhibitor targeting the CYP51 enzyme, a key component in the ergosterol biosynthesis pathway. This compound is of significant value for researchers investigating fungal biology, antifungal drug resistance mechanisms, and for use as a biochemical tool in high-throughput screening assays. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel antifungal agents and studying sterol metabolism.

Application

• Antifungal Research & Development: Serves as a critical biochemical tool for studying the mechanism of action of azole-class antifungal drugs and for screening new candidate compounds.
• Biochemical Pathway Analysis: Used to specifically inhibit CYP51 (14α-demethylase) in vitro to elucidate its role in ergosterol synthesis and membrane integrity in fungi and protozoa.
• Drug Resistance Studies: Essential for investigating mutations in the CYP51 gene that confer resistance to clinical antifungal agents like fluconazole and itraconazole.
• High-Throughput Screening (HTS): Employed as a reference standard or positive control in cell-based and enzymatic assays designed to discover new CYP51 inhibitors.
• Parasitology Research: Applied in studies targeting Trypanosoma and Leishmania species, which utilize similar sterol biosynthesis pathways, for potential antiparasitic drug discovery.

Basic Information

Product Name	Cytochrome P450 14A-Demethylase Inhibitor 1D
CAS No.	1155361-02-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CYP51 Inhibitor 1D; 14α-Demethylase Inhibitor 1D; Sterol 14α-Demethylase Inhibitor; Lanosterol 14α-Demethylase Inhibitor; Antifungal Research Compound 1155361-02-6; CYP Inhibitor Screening Tool; Azole Synergy Research Compound
EINECS	Contact for details

Quality Control

Our Cytochrome P450 14A-Demethylase Inhibitor 1D is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and assay results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the product label or COA. For long-term storage, keep desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.