Description

Cytochrome P450 14A-Demethylase Inhibitor 1A is a potent and selective small-molecule inhibitor targeting the CYP51 enzyme, a key component in the sterol biosynthesis pathway. This compound is a critical research tool for studying fungal and protozoan infections, as well as cholesterol metabolism, due to its ability to disrupt essential membrane integrity. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel antifungal and antiparasitic therapeutics.

Application

• Antifungal Drug Discovery: Serves as a lead compound or reference standard in the development of new azole and non-azole antifungal agents targeting Candida, Aspergillus, and other pathogenic fungi.
• Parasitology Research: Used to investigate and validate CYP51 as a drug target for treating neglected tropical diseases caused by trypanosomes and leishmania.
• Biochemical Assay Development: Employed as a precise inhibitor in high-throughput screening (HTS) and enzyme inhibition assays to characterize CYP450 enzyme activity and selectivity.
• Sterol Biosynthesis Studies: A key reagent for elucidating the ergosterol (fungi) and cholesterol (mammals) biosynthesis pathways in metabolic research.
• Veterinary Medicine Research: Investigated for potential applications in treating fungal infections in agricultural and companion animals.
• Mechanism of Action Studies: Utilized to study resistance mechanisms in fungal pathogens and to design next-generation inhibitors with improved efficacy.

Basic Information

Product Name	Cytochrome P450 14A-Demethylase Inhibitor 1A
CAS No.	1155360-99-8
Molecular Formula	C₂₀H₂₀F₃N₅O₂
Molecular Weight	419.40 g/mol
Synonyms	CYP51 Inhibitor 1A; CYP450 14DM Inhibitor; (2R,4S)-N-(4-{4-[(3S)-3-Fluoropyrrolidin-1-yl]pyridin-2-yl}phenyl)-2-(4-fluorophenyl)-4-methyl-4,5-dihydro-1,3-oxazole-4-carboxamide; VNI; (R,S)-VNI; Sterol 14α-demethylase inhibitor; Lanosterol 14α-demethylase inhibitor; Antifungal lead compound VNI
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with research-grade standards. Identity, purity, and potency are verified using advanced analytical techniques including HPLC, NMR, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under desiccant. Allow the product to equilibrate to room temperature before opening to prevent moisture condensation. Store in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (IC₅₀)	Reported value provided per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.