Description

2,3-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a high-value, multi-functional boronic ester derivative, prized for its role as a key synthetic intermediate in modern organic chemistry. Its primary commercial value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for R&D chemists and process development scientists working in pharmaceutical, agrochemical, and specialty chemical synthesis, where the introduction of a pyridine core with specific fluorine substitution patterns is required.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoropyridine moiety can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized nitrogen-containing ligands used in homogeneous catalysis and material science applications.
• Functional Material Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and organic semiconductors, where fluorination tunes electronic properties.
• Custom Chemical Synthesis: A versatile reagent for contract research organizations (CROs) and CDMOs to produce bespoke compounds for client projects.
• Academic & Industrial R&D: A fundamental tool in medicinal chemistry and process chemistry laboratories for exploring new chemical spaces and optimizing synthetic routes.

Basic Information

Item	Details
Product Name	2,3-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.	1154579-82-4
Molecular Formula	C11H14BF2NO2
Molecular Weight	241.05 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-difluoropyridine; 2,3-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)pyridine; 2,3-Difluoropyridine-5-boronic acid pinacol ester; (2,3-Difluoropyridin-5-yl)boronic acid pinacol ester; 2,3-Difluoro-5-pyridineboronic acid pinacol ester; Pinacol (2,3-difluoropyridin-5-yl)boronate; 5-(Pinacolatoboryl)-2,3-difluoropyridine; CAS 1154579-82-4
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.