Description

Methyl 3-(Chlorosulfonyl)-2,5-Difluorobenzoate is a high-purity, multi-functional chemical intermediate designed for advanced synthesis. Its core value lies in the strategic combination of a reactive chlorosulfonyl group and a benzoate ester, enabling precise molecular construction in complex chemical processes. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoro and chlorosulfonyl motifs contribute to enhanced biological activity and environmental stability.
• Liquid Crystal Material Precursor: Serves as a critical intermediate in the manufacture of fluorinated liquid crystals for high-performance displays.
• Polymer Modification Agent: Employed to introduce sulfonyl chloride functionality into polymer backbones for creating specialty polymers with tailored properties.
• Organic Synthesis Reagent: Utilized in research laboratories for constructing complex heterocyclic compounds and facilitating sulfonamide coupling reactions.
• Chemical Probe Development: Acts as a starting material for creating fluorescent dyes and molecular probes used in biochemical assays and diagnostics.

Basic Information

Product Name	Methyl 3-(Chlorosulfonyl)-2,5-Difluorobenzoate
CAS No.	1154149-20-8
Molecular Formula	C8H5ClF2O4S
Molecular Weight	270.64 g/mol
Synonyms	3-(Chlorosulfonyl)-2,5-difluorobenzoic Acid Methyl Ester; Methyl 2,5-Difluoro-3-(chlorosulfonyl)benzoate; Benzoic acid, 3-(chlorosulfonyl)-2,5-difluoro-, methyl ester; 2,5-Difluoro-3-(chlorosulfonyl)benzoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-(Chlorosulfonyl)-2,5-Difluorobenzoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Every lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and we support compliance with cGMP, ISO, and REACH standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.