Description

Flupirtine-N2-β-D-Glucuronide is a key metabolite of the centrally acting, non-opioid analgesic flupirtine. This compound is of significant value in pharmaceutical research and development, particularly for drug metabolism and pharmacokinetic (DMPK) studies. It is essential for scientists in analytical chemistry and pharmacology who require high-purity reference standards for bioanalytical method development, metabolite identification, and regulatory toxicology assessments.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative and qualitative analysis of flupirtine metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Critical for in vitro and in vivo studies to understand the metabolic pathway, clearance, and exposure of flupirtine.
• Bioanalytical Method Development: Used to validate HPLC, LC-MS, and LC-MS/MS methods for accurate detection and quantification in plasma, serum, and urine.
• Toxicology and Safety Assessment: Employed in studies to investigate the safety profile and potential toxicity of flupirtine metabolites.
• Clinical Research: Supports clinical trials by enabling precise monitoring of metabolite levels in patient samples.
• Impurity Profiling: Acts as a characterized impurity standard in the quality control of flupirtine active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	Flupirtine-N2-β-D-Glucuronide
CAS No.	1147289-74-4
Molecular Formula	C23H26FN3O9
Molecular Weight	507.47 g/mol
Synonyms	Flupirtine N2-Glucuronide; Flupirtine N-β-D-Glucuronide; Flupirtine Glucuronide Metabolite; 2-[4-Fluoro-2-[[2-(1-methylethyl)amino]pyridin-3-yl]carbamoyl]phenyl] N-(β-D-Glucopyranosyluronate); 1-[[3-[[[2-[[(2,3,4,5,6-Pentahydroxyhexyl)oxy]carbonyl]-5-fluorophenyl]amino]carbonyl]-2-pyridinyl]amino]-2-propanol; Katadolon Metabolite
EINECS	Contact for details

Quality Control

Our Flupirtine-N2-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.