Description

Flupirtine-N6-β-D-Glucuronide is a key glucuronide metabolite of the centrally acting, non-opioid analgesic flupirtine. This compound is of significant value in pharmaceutical research and development, particularly for metabolic profiling, pharmacokinetic studies, and the development of analytical reference standards. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and safety evaluation.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification of flupirtine metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for in vitro and in vivo studies to understand the metabolic pathways and clearance mechanisms of flupirtine.
• Bioanalytical Method Development: Used as a standard for developing and validating sensitive HPLC-MS/MS or LC-MS methods for therapeutic drug monitoring.
• Toxicology and Safety Assessment: Employed in studies to investigate the safety profile and potential toxicity associated with flupirtine's major metabolites.
• Impurity Characterization: Acts as an identified impurity standard in the quality control of flupirtine active pharmaceutical ingredient (API) and finished drug products.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) to demonstrate comprehensive understanding of a drug's metabolic fate.

Basic Information

Product Name	Flupirtine-N6-β-D-Glucuronide
CAS No.	1147289-72-2
Molecular Formula	C23H26FN3O9
Molecular Weight	507.47 g/mol
Synonyms	Flupirtine N6-Glucuronide; Flupirtine Glucuronide Metabolite; N6-(β-D-Glucopyranuronosyl)flupirtine; Flupirtine-6-glucuronide; D 13223 Glucuronide; Ethyl {2-Amino-6-[(4-fluorobenzyl)amino]-3-pyridinyl}carbamate N6-Glucuronide; Katadolon Metabolite
EINECS	Contact for details

Quality Control

Our Flupirtine-N6-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.