Description

Cal-101 is a potent and selective small molecule inhibitor of the delta isoform of phosphoinositide 3-kinase (PI3Kδ). This compound matters for its critical role in targeted research and development, particularly in the study of B-cell receptor signaling pathways and immune cell function. It is primarily needed by pharmaceutical researchers, biotechnology companies, and academic institutions focused on oncology, immunology, and inflammatory disease research. The product is supplied under the identifier CAS NO 1146702-54-6.

Application

• Biochemical Research: A key tool for studying the specific role of PI3Kδ in cellular signaling cascades and immune cell activation.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in preclinical studies for hematologic cancers and autoimmune disorders.
• Oncology Research: Investigated for its potential therapeutic effects in B-cell malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma.
• Immunology Studies: Applied to modulate B-cell and T-cell activity, useful for research into inflammation and immune-mediated diseases.
• Mechanistic Studies: Employed to elucidate pathways involving B-cell receptor signaling and to validate PI3Kδ as a therapeutic target.
• High-Throughput Screening (HTS): Serves as a control compound in assay development and screening campaigns for novel PI3K inhibitors.

Basic Information

Product Name	Cal-101
CAS No.	1146702-54-6
Molecular Formula	C₂₂H₁₈FN₇O₃
Molecular Weight	447.42 g/mol
Synonyms	GS-1101; Idelalisib; 5-Fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]-4(3H)-quinazolinone; CAL-101; PI3Kδ Inhibitor; Phosphoinositide 3-kinase delta inhibitor; Zydelig (Pharmaceutical Grade)
EINECS	Contact for details

Quality Control

Our Cal-101 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity confirmation and identity verification via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.