Description

(R)-2-(Bis(3,5-Bis(Trifluoromethyl)Phenyl)(tert-Butyldimethylsilyloxy)Methyl)Pyrrolidine is a sophisticated chiral organofluorine compound that serves as a high-value building block and ligand in advanced synthetic chemistry. Its molecular architecture, featuring electron-deficient trifluoromethylphenyl groups and a silyl-protected pyrrolidine scaffold, makes it an essential reagent for inducing stereoselectivity in complex catalytic transformations. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Asymmetric Catalysis: Employed as a chiral ligand or catalyst in transition metal-catalyzed reactions, such as hydrogenations, cross-couplings, and C-H functionalizations, to produce enantiomerically pure compounds.
• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Research: Used in the development of enantiomerically pure pesticides and herbicides, where the specific stereochemistry is crucial for biological activity and environmental safety.
• Material Science: Serves as a precursor for creating advanced fluorinated polymers or liquid crystals with unique electronic and surface properties.
• Methodology Development: A valuable tool for academic and industrial chemists developing new catalytic methodologies and exploring structure-activity relationships (SAR).

Basic Information

Product Name	(R)-2-(Bis(3,5-Bis(Trifluoromethyl)Phenyl)(tert-Butyldimethylsilyloxy)Methyl)Pyrrolidine
CAS No.	1146629-74-4
Molecular Formula	C31H30F12NOSi
Molecular Weight	688.66 g/mol
Synonyms	(R)-2-((Bis(3,5-bis(trifluoromethyl)phenyl)((tert-butyldimethylsilyl)oxy)methyl)pyrrolidine; (R)-TBS-Bis(3,5-(CF3)2C6H3) Pyrrolidine Methanol Derivative; (R)-2-[(tert-Butyldimethylsilyl)oxy(bis[3,5-bis(trifluoromethyl)phenyl])methyl]pyrrolidine; Chiral Pyrrolidine Silyl Ether Ligand; (R)-DTBM-SEGPHOS Related Pyrrolidine; (R)-Proline-derived Trifluoromethyl Aryl Ligand; CAS 1146629-74-4
EINECS	Contact for details

Quality Control

Our production of (R)-2-(Bis(3,5-Bis(Trifluoromethyl)Phenyl)(tert-Butyldimethylsilyloxy)Methyl)Pyrrolidine adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for sensitive catalytic applications. Each lot is characterized by advanced analytical techniques including Chiral HPLC, 1H/19F/13C NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (argon or nitrogen) when not in use to prevent moisture absorption and decomposition. Keep away from incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.