Description

3-Methoxy-5-(Trifluoromethyl)Benzenesulphonyl Chloride is a specialized aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its dual functionality, where the sulfonyl chloride group acts as a highly reactive electrophile for forming sulfonamides and sulfonate esters, while the methoxy and trifluoromethyl substituents impart unique electronic and steric properties to the final molecule. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require high-purity intermediates for developing new active ingredients, particularly in creating sulfonamide-based drugs and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel sulfonamide-based drug candidates, including protease inhibitors, kinase inhibitors, and antibacterial agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Building block for creating specialized polymers, liquid crystals, and organic electronic materials that benefit from its specific aromatic structure.
• Chemical Research: A versatile reagent in academic and industrial R&D for exploring new reaction pathways and creating complex molecular architectures.
• Dye and Pigment Industry: Intermediate in the production of high-performance, light-fast dyes and functional pigments.

Basic Information

Product Name	3-Methoxy-5-(Trifluoromethyl)Benzenesulphonyl Chloride
CAS No.	1146355-33-0
Molecular Formula	C8H6ClF3O3S
Molecular Weight	274.64 g/mol
Synonyms	3-Methoxy-5-(trifluoromethyl)benzenesulfonyl chloride; 5-(Trifluoromethyl)-3-methoxybenzenesulfonyl chloride; 3-Methoxy-α,α,α-trifluoro-m-toluenesulfonyl chloride; m-Methoxy-α,α,α-trifluorotoluenesulfonyl chloride; 1-Methoxy-3-(trifluoromethyl)-5-benzenesulfonyl chloride; 3-Methoxy-5-trifluoromethylphenylsulfonyl chloride; (3-Methoxy-5-trifluoromethylphenyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 3-Methoxy-5-(Trifluoromethyl)Benzenesulphonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis using advanced techniques like HPLC, GC, and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment, supporting your quality management systems and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from strong bases, oxidizing agents, and sources of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.