Description

Trabectedin is a potent marine-derived antineoplastic agent, specifically a tetrahydroisoquinoline alkaloid. This compound is of significant commercial and clinical interest for its unique mechanism of action, which involves binding to the minor groove of DNA and interfering with transcription-coupled nucleotide excision repair. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug development and production.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of injectable oncology therapeutics.
• Reference Standard in analytical laboratories for quality control and method validation of drug products.
• Biochemical Research for studying DNA repair mechanisms, transcription regulation, and cancer cell biology.
• Preclinical Development for efficacy and toxicology studies in novel drug candidate pipelines.
• Pharmaceutical Intermediates in the synthesis of more complex drug candidates or analogs.

Basic Information

Product Name	Trabectedin
CAS No.	1144899-77-3
Molecular Formula	C₃₉H₄₃N₃O₁₁S
Molecular Weight	761.84 g/mol
Synonyms	ET-743; Ecteinascidin 743; Yondelis (trade name); NSC 684766; 6',7'-Didehydro-5,6-dihydro-4'-demethoxy-7',14'-dioxo-7'H-spiro[2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzoxazine-3,4'-pyrano[3,2-b]acridine]-7-carboxylic acid, 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-ylmethyl ester
EINECS	Contact for details

Quality Control

Our Trabectedin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) detailing results from HPLC, NMR, and MS are provided and can be tailored to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Microbial Limits	Meets Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.