Description

n-Acetyl-10-Deacetyl-n-Debenzoylpaclitaxel is a key synthetic intermediate in the production of paclitaxel and its potent derivatives. This compound is critical for pharmaceutical research and development, enabling the creation of novel chemotherapeutic agents with potentially improved efficacy and safety profiles. It is primarily utilized by advanced pharmaceutical manufacturers and research institutions engaged in oncology drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of paclitaxel (Taxol®) and related taxane-based anticancer drugs.
• Oncology Research: Used in medicinal chemistry programs to develop and evaluate new paclitaxel analogs with modified pharmacological properties.
• Process Development: Serves as a reference standard and starting material for optimizing scalable, cost-effective manufacturing routes for taxane APIs.
• Metabolite Studies: Employed in analytical research to study the metabolic pathways and degradation products of paclitaxel.
• Impurity Standard: Acts as a certified reference material (CRM) for quality control, ensuring the purity and consistency of final drug products.

Basic Information

Product Name	n-Acetyl-10-Deacetyl-n-Debenzoylpaclitaxel
CAS No.	1144034-42-3
Molecular Formula	C31H35NO11
Molecular Weight	597.61 g/mol
Synonyms	10-Deacetyl-N-debenzoyl-N-acetylpaclitaxel; 7,10-Dideacetyl-10-acetylpaclitaxel; Taxol Intermediate; Paclitaxel Derivative; 2'-O-Acetylpaclitaxel (related); 10-Deacetyl-N-debenzoyl-N-acetyl Taxol; n-Acetyl-10-deacetyl-n-debenzoyltaxol
EINECS	Contact for details

Quality Control

Our n-Acetyl-10-Deacetyl-n-Debenzoylpaclitaxel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with full traceability are provided and can be tailored to support regulatory filings (e.g., DMF, CMC sections).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.