Description

5-Bromo-1,2-difluoro-3-methylbenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists developing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoro and bromo substituents contribute to biological activity and metabolic stability.
• Liquid Crystal Materials (LCs): Serves as a core building block for the synthesis of fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the development of organic semiconductors and charge-transport materials due to its halogenated aromatic structure.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create more complex biaryl structures.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new synthetic methodologies and material properties.

Basic Information

Product Name	5-Bromo-1,2-difluoro-3-methylbenzene
CAS No.	1143502-75-3
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	3-Bromo-2,6-difluorotoluene; 1-Bromo-2,3-difluoro-4-methylbenzene; 2,6-Difluoro-3-bromotoluene; 5-Bromo-2,3-difluorotoluene; Benzene, 5-bromo-1,2-difluoro-3-methyl-; 1143502-75-3
EINECS	Contact for details

Quality Control

Our 5-Bromo-1,2-difluoro-3-methylbenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent quality suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.