Description

1-Bromo-2,3-Difluoro-5-Methylbenzene is a high-purity halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists working on active ingredients, functional materials, and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the difluoro and bromo groups modulate biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the introduction of the 2,3-difluoro-5-methylphenyl moiety into complex architectures.
• Chemical Research & Development: Employed in academic and industrial labs for method development, library synthesis, and exploring new reaction pathways in organofluorine chemistry.

Basic Information

Product Name	1-Bromo-2,3-Difluoro-5-Methylbenzene
CAS No.	1143502-74-2
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	2,3-Difluoro-5-methylbromobenzene; 2-Bromo-1,3-difluoro-5-methylbenzene; 3-Bromo-2,6-difluorotoluene; 5-Methyl-2,3-difluorobromobenzene; 1-Bromo-2,3-difluoro-5-methyl-benzene; (2,3-Difluoro-5-methylphenyl)bromide; Toluene, 3-bromo-2,6-difluoro-
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,3-Difluoro-5-Methylbenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent lot-to-lot performance. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.