Description

3-Bromo-4,5-Difluorobenzaldehyde is a high-value, multi-functional aromatic aldehyde building block characterized by its halogen and fluorine substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling the synthesis of advanced materials and active pharmaceutical ingredients. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro motif enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystal compounds and electron-transport materials in organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl systems.
• Ligand & Catalyst Development: Employed in the synthesis of novel fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile building block for academic and industrial R&D in medicinal chemistry, materials science, and synthetic methodology.

Basic Information

Product Name	3-Bromo-4,5-Difluorobenzaldehyde
CAS No.	1143502-70-8
Molecular Formula	C7H3BrF2O
Molecular Weight	221.00 g/mol
Synonyms	4,5-Difluoro-3-bromobenzaldehyde; 3-Bromo-4,5-difluorobenzenecarboxaldehyde; Benzaldehyde, 3-bromo-4,5-difluoro-; 1143502-70-8; 3-Br-4,5-F2-benzaldehyde
EINECS	Contact for details

Quality Control

Our 3-Bromo-4,5-Difluorobenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.