Description

1-(1,1-Difluoroethyl)-4-Iodobenzene is a high-purity, fluorinated and iodinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a difluoroethyl moiety with an iodine atom on the benzene ring, making it a versatile precursor for cross-coupling reactions and the introduction of fluorine-containing groups. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting fluorine-containing bioactive molecules.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the difluoroethyl group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings to form complex biaryl structures.
• Fluorine Chemistry: The 1,1-difluoroethyl group is a valuable synthon for further fluorination or as a stable bioisostere in drug design.
• Ligand Synthesis: Can be utilized to create novel ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Item	Detail
Product Name	1-(1,1-Difluoroethyl)-4-Iodobenzene
CAS No.	1142924-89-7
Molecular Formula	C8H7F2I
Molecular Weight	268.05 g/mol
Synonyms	4-Iodo-α,α-difluoroethylbenzene; 1-(4-Iodophenyl)-1,1-difluoroethane; p-(1,1-Difluoroethyl)iodobenzene; 1,1-Difluoro-1-(4-iodophenyl)ethane; Benzene, 1-(1,1-difluoroethyl)-4-iodo-; 4-(1,1-Difluoroethyl)iodobenzene; 1-(Difluoroethyl)-4-iodobenzene
EINECS	Contact for details

Quality Control

Our 1-(1,1-Difluoroethyl)-4-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.