Description

Gsk-3β Inhibitor Xviii is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 beta (GSK-3β), a key enzyme involved in numerous cellular signaling pathways. This compound is a critical research tool for studying the role of GSK-3β in diseases such as cancer, neurodegenerative disorders, diabetes, and inflammation. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in drug discovery and biochemical pathway analysis. The high specificity of this inhibitor makes it invaluable for validating GSK-3β as a therapeutic target and for preclinical studies.

Application

• Biochemical Research: Used as a selective tool compound to inhibit GSK-3β activity in in vitro enzyme assays and cell-based studies.
• Drug Discovery & Development: Serves as a lead compound or reference standard in pharmaceutical R&D for oncology, neurology, and metabolic disease programs.
• Academic Research: Employed in neuroscience labs to investigate the role of GSK-3β in Alzheimer's disease, Parkinson's disease, and other tauopathies.
• Signal Transduction Studies: Essential for probing the Wnt/β-catenin, PI3K/Akt, and other pathways where GSK-3β is a regulatory node.
• Stem Cell Research: Applied in studies to modulate differentiation and self-renewal pathways in pluripotent stem cells.
• Inflammation & Immunology: Used to study the anti-inflammatory effects of GSK-3β inhibition in immune cell models.

Basic Information

Product Name	Gsk-3β Inhibitor Xviii
CAS No.	1139875-74-3
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	GSK-3β Inhibitor XVIII; 6-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinecarbonitrile; GSK-3 Inhibitor X; CAS 1139875-74-3; 6-({4-[4-Methylpiperazin-1-yl]phenyl}amino)pyrimidine-4-carbonitrile; GSK3β Inhibitor 10; GSK-3β Inhibitor (6-((4-(4-Methylpiperazin-1-yl)phenyl)amino)pyrimidine-4-carbonitrile)
EINECS	Contact for details

Quality Control

Our Gsk-3β Inhibitor Xviii is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications for that batch. We adhere to relevant quality management standards to support your critical research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.