Description

Cx-5461 is a potent and selective small molecule inhibitor of RNA polymerase I transcription, specifically targeting the SL1/TIF-IA complex. This compound is a critical research tool for studying ribosomal biogenesis, nucleolar stress, and their roles in cellular processes and disease models. It is primarily utilized by researchers and scientists in the fields of oncology, molecular biology, and pharmacology for in vitro and in vivo studies.

Application

• Biomedical Research: Fundamental studies on ribosomal RNA (rRNA) synthesis and nucleolar function.
• Oncology Research: Investigation of cancer cell survival mechanisms, particularly in p53-dependent and -independent pathways.
• Drug Discovery: A reference compound for screening and developing novel therapeutics targeting transcription dysregulation.
• Cell Biology: Tool for inducing nucleolar stress and studying its downstream effects on cell cycle arrest and apoptosis.
• Preclinical Studies: Used in animal models to evaluate the therapeutic potential of Pol I inhibition for various cancers.

Basic Information

Product Name	Cx-5461
CAS No.	1138549-36-6
Molecular Formula	C₂₄H₂₇N₅O₄
Molecular Weight	449.50 g/mol
Synonyms	CX 5461; CX-5461; 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 4-methyl-1-[(4-methylphenyl)sulfonyl]-6-[[(3R,5S)-3,4,5-trimethyl-1-piperazinyl]carbonyl]-; Pol I Inhibitor CX-5461; RNA Polymerase I Inhibitor CX-5461; SL1/TIF-IA Complex Inhibitor
EINECS	Contact for details

Quality Control

Our Cx-5461 is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.