Description

1-(1,1-Difluoroethyl)-4-(Trifluoromethyl)Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique trifluoromethyl and difluoroethyl substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by R&D and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a fluorinated core structure in the synthesis of electronic materials for displays and organic light-emitting diodes, improving charge transport and stability.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to produce specialty fluoropolymers with enhanced chemical resistance, thermal stability, and low surface energy.
• Catalyst Ligand Development: Utilized in the design of novel ligands for transition metal catalysis, enabling new and more efficient synthetic transformations.

Basic Information

Product Name	1-(1,1-Difluoroethyl)-4-(Trifluoromethyl)Benzene
CAS No.	1138445-30-3
Molecular Formula	C9H7F5
Molecular Weight	210.15 g/mol
Synonyms	α,α-Difluoroethylbenzene, 4-(Trifluoromethyl)-; 4-(Trifluoromethyl)-1-(1,1-difluoroethyl)benzene; 1-(1,1-Difluoroethyl)-4-(trifluoromethyl)benzene; 1-Difluoroethyl-4-trifluoromethylbenzene; p-(1,1-Difluoroethyl)benzotrifluoride; Benzene, 1-(1,1-difluoroethyl)-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-(1,1-Difluoroethyl)-4-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and fluorides. Recommended storage temperature is between 2°C and 25°C. The container should be kept tightly sealed in a dry environment to minimize moisture uptake and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.