Description

1-(1,1-Difluoroethyl)-2,4-Difluorobenzene is a high-value, multi-fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both a difluoroethyl and difluorophenyl moiety, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Intermediate: Used in the research and development of new-generation herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials requiring specific fluorine-based properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a versatile scaffold for constructing complex, fluorinated molecular architectures in medicinal chemistry.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a precursor for synthesizing fluorine-18 labeled radiopharmaceuticals for diagnostic imaging.

Basic Information

Product Name	1-(1,1-Difluoroethyl)-2,4-Difluorobenzene
CAS No.	1138445-07-4
Molecular Formula	C10H8F4
Molecular Weight	204.16 g/mol
Synonyms	2,4-Difluoro-1-(1,1-difluoroethyl)benzene; 1-(2,4-Difluorophenyl)-1,1-difluoroethane; α,α-Difluoro-2,4-difluoroethylbenzene; (2,4-Difluorophenyl)difluoroethane; 1,1-Difluoro-1-(2,4-difluorophenyl)ethane; Difluoro(2,4-difluorophenyl)ethane
EINECS	Contact for details

Quality Control

Our production of 1-(1,1-Difluoroethyl)-2,4-Difluorobenzene adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is fully characterized using advanced analytical techniques including GC, HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.