Description

2-Bromo-1-(1,1-Difluoroethyl)-4-Fluorobenzene is a high-value, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromine, fluorine, and a difluoroethyl group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Employed in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Used to create sophisticated ligands for transition metal catalysis, enabling new asymmetric synthesis and cross-coupling methodologies.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Bromo-1-(1,1-Difluoroethyl)-4-Fluorobenzene
CAS No.	1138444-86-6
Molecular Formula	C8H6BrF3
Molecular Weight	239.04 g/mol
Synonyms	1-Bromo-2-(1,1-difluoroethyl)-5-fluorobenzene; 4-Fluoro-2-bromo-α,α-difluoroethylbenzene; 2-Bromo-α,α-difluoro-4-fluoroethylbenzene; (2-Bromo-4-fluorophenyl)(1,1-difluoro)ethane; Benzene, 2-bromo-1-(1,1-difluoroethyl)-4-fluoro-
EINECS	Contact for details

Quality Control

We supply 2-Bromo-1-(1,1-Difluoroethyl)-4-Fluorobenzene in high-purity grades suitable for demanding R&D and scale-up applications. Every batch is characterized and controlled using advanced analytical techniques including GC, HPLC, NMR, and MS to ensure identity, purity, and lot-to-lot consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality system is designed to support regulatory filings in target industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its properties as a fluoride/strong alkali and highly volatile compound, ensure containers are kept tightly sealed and away from incompatible materials. Keep under an inert atmosphere if prolonged storage is required.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.