Description

n-Cyclopropyl Bimatoprost CAS NO 1138395-12-6 is a high-purity, synthetic prostaglandin analog derivative, representing a key advanced intermediate in modern pharmaceutical synthesis. This compound is of critical importance for the development and production of next-generation ophthalmic and dermatological treatments, particularly those targeting intraocular pressure and hair growth. It is primarily required by pharmaceutical R&D laboratories, API manufacturers, and fine chemical suppliers serving the global life sciences sector.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A crucial building block in the synthesis of novel prostaglandin-based APIs.
• Ophthalmic Drug Development: Used in research and production of new-generation glaucoma and ocular hypertension medications.
• Dermatological & Cosmetic Applications: Serves as a precursor in formulations being investigated for hair growth stimulation and other dermatological uses.
• Biochemical Research: Employed as a reference standard and probe compound in pharmacological studies of prostaglandin receptors.
• Process Chemistry & Scale-Up: Utilized in process optimization and pilot-scale manufacturing of specialty pharmaceuticals.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	n-Cyclopropyl Bimatoprost
CAS No.	1138395-12-6
Molecular Formula	C25H37NO4
Molecular Weight	415.57 g/mol
Synonyms	7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenamide, Cyclopropyl Bimatoprost; Bimatoprost Cyclopropyl Analog; Bimatoprost Impurity; Prostaglandin F2α Ethanolamide Derivative; (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]hept-5-enoic Acid N-Ethylamide
EINECS	Contact for details

Quality Control

Our n-Cyclopropyl Bimatoprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets stringent specifications for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications. We support development under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen) after opening to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.