Description

5-Fluoro-2-(Piperidin-4-yl)pyridine is a high-value pharmaceutical intermediate and versatile heterocyclic building block. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small-molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate its unique piperidine-pyridine scaffold into novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other biologically active molecules targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its privileged structure that can modulate drug-like properties.
• Agrochemical Development: Serves as a precursor in the research and synthesis of novel herbicides and fungicides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring specific fluorinated piperidine derivatives.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	5-Fluoro-2-(Piperidin-4-yl)pyridine
CAS No.	1138217-86-3
Molecular Formula	C10H13FN2
Molecular Weight	180.22 g/mol
Synonyms	4-(5-Fluoropyridin-2-yl)piperidine; 2-(4-Piperidinyl)-5-fluoropyridine; 5-Fluoro-2-(4-piperidinyl)pyridine; 5-Fluoro-2-piperidin-4-ylpyridine; 1138217-86-3; 5-Fluoro-2-(piperidin-4-yl)pyridine; 5-Fluoro-2-(4-piperidyl)pyridine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Piperidin-4-yl)pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. We provide full traceability and detailed Certificates of Analysis (COA) for all shipments, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.