Description

5-Fluoro-2-(Piperidin-4-Yl)Pyridine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of kinase inhibitors for oncology and inflammatory diseases.
• Drug Discovery Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Biology: Serves as a molecular probe or scaffold for studying biological pathways and protein-ligand interactions.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for candidate drugs under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis: A starting material for the contract manufacturing of specialized APIs and novel chemical entities (NCEs).

Basic Information

Product Name	5-Fluoro-2-(Piperidin-4-Yl)Pyridine Dihydrochloride
CAS No.	1137949-75-7
Molecular Formula	C10H14FN2·2HCl
Molecular Weight	265.15 g/mol (Free base: 178.23 g/mol)
Synonyms	5-Fluoro-2-(4-piperidinyl)pyridine dihydrochloride; 2-(Piperidin-4-yl)-5-fluoropyridine dihydrochloride; 4-(5-Fluoropyridin-2-yl)piperidine dihydrochloride; 5-Fluoro-2-piperidin-4-ylpyridine dihydrochloride; 1137949-75-7; 5-Fluoro-2-(4-piperidyl)pyridine dihydrochloride
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Piperidin-4-Yl)Pyridine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.