Description

Q-Vd-Oph Hydrate is a potent and selective small molecule inhibitor of the anti-apoptotic protein Bcl-2. This compound is a critical research tool for studying programmed cell death pathways and has significant potential in the development of novel cancer therapeutics. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors focused on oncology, apoptosis research, and high-throughput screening for drug discovery.

Application

• Apoptosis Research: A key biochemical tool for investigating the intrinsic (mitochondrial) pathway of programmed cell death and Bcl-2 protein family interactions.
• Oncology Drug Discovery: Used in high-throughput screening assays to identify and validate new anti-cancer compounds that target Bcl-2 mediated survival pathways.
• Biochemical Assay Development: Serves as a reference standard and positive control in developing in vitro assays to measure caspase activation and cytochrome c release.
• Cell Biology Studies: Employed to sensitize cancer cell lines to chemotherapeutic agents by inhibiting Bcl-2, helping to study drug resistance mechanisms.
• Preclinical Research: Utilized in animal model studies to evaluate the efficacy of Bcl-2 inhibition as a therapeutic strategy for various cancers.

Basic Information

Product Name	Q-Vd-Oph Hydrate
CAS No.	1135695-98-5
Molecular Formula	C₂₃H₂₂N₄O₄ • xH₂O
Molecular Weight	Anhydrous: 418.45 g/mol
Synonyms	Q-VD-OPh Hydrate; Quinoline-Val-Asp-Difluorophenoxymethylketone Hydrate; (S)-2-((S)-2-(6-Chloro-2-quinolinyl)-2-((2,4-difluorophenoxy)acetyl)amino)acetyl)amino)-5-((tetrahydro-2H-pyran-4-yl)oxy)pentanoic Acid Hydrate; QVD-OPH Hydrate; Caspase Inhibitor Q-VD-OPh Hydrate; Broad-spectrum Caspase Inhibitor QVD-OPh Hydrate
EINECS	Contact for details

Quality Control

Our Q-Vd-Oph Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and Karl Fischer titration for water content. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.