Description

Caspase Inhibitor I, Biotin Conjugate is a high-purity biochemical tool compound designed for advanced apoptosis research. This biotinylated derivative of the pan-caspase inhibitor Z-VAD-FMK enables sensitive detection and pull-down assays, facilitating the study of programmed cell death pathways. It is an essential reagent for researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on oncology, neurobiology, and immunology. The product, identified by CAS NO 1135688-15-1, offers a critical link between caspase activity and downstream analytical techniques.

Application

• Biomarker Discovery & Validation: Used in pull-down assays to identify and characterize caspase substrates and binding partners in complex biological samples.
• Apoptosis Pathway Analysis: Enables the specific labeling and detection of active caspases in cell lysates and tissue sections via streptavidin-based detection systems (e.g., ELISA, Western Blot, fluorescence microscopy).
• High-Throughput Screening (HTS): Serves as a key component in screening platforms designed to discover novel modulators of caspase activity for drug development.
• Mechanistic Studies in Disease Models: Applied in research on cancer, neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), and ischemic injury to elucidate the role of specific caspases.
• Diagnostic Assay Development: Utilized in the development of clinical diagnostic tools to measure caspase activation as an indicator of disease progression or therapeutic efficacy.

Basic Information

Product Name	Caspase Inhibitor I, Biotin Conjugate
CAS No.	1135688-15-1
Molecular Formula	C33H48N8O9S2
Molecular Weight	764.91 g/mol
Synonyms	Z-VAD-FMK Biotin Conjugate; Biotin-VAD-FMK; Biotinylated Caspase Inhibitor I; (S)-5-(Biotinamido)pentyl N-((S)-1-((S)-3-Methyl-1-(((S)-3-methyl-1-oxo-1-((5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentyl)amino)butan-2-yl)amino)-1-oxobutan-2-yl)amino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)carbamate; Biotin-Z-VAD-FMK; Caspase Inhibitor I-Biotin; Biotin Labeled Z-VAD-FMK
EINECS	Contact for details

Quality Control

Every batch of Caspase Inhibitor I, Biotin Conjugate is manufactured under strict quality protocols and undergoes comprehensive analytical testing to ensure identity, purity, and biological activity. Our quality system is designed to meet the rigorous demands of research and pre-clinical development. Certificates of Analysis (COA) detailing purity (by HPLC), molecular weight confirmation (MS), and functional activity data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Biological Activity	Inhibits caspase activity in cell-based assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.