Description

Benzyl (R)-3-(Chlorosulfonyl)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its core value lies in its reactive chlorosulfonyl group and protected pyrrolidine scaffold, enabling precise chemical transformations in complex synthesis. This compound is essential for research and production teams in the pharmaceutical and fine chemical industries, particularly those developing novel active pharmaceutical ingredients (APIs) and chiral molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological and metabolic disorders.
• Protease Inhibitor Development: Serves as a critical precursor for constructing pharmacophores in the design of protease inhibitors, including renin and DPP-4 inhibitors.
• Peptidomimetic Chemistry: Used to introduce constrained pyrrolidine units into peptide backbones, enhancing metabolic stability and bioavailability of peptide-based therapeutics.
• Sulfonamide & Sulfonyl Chloride Chemistry: The reactive chlorosulfonyl moiety allows for the efficient introduction of sulfonamide groups, a common pharmacophore in medicinal chemistry.
• Asymmetric Synthesis: The (R)-configured stereocenter provides a chiral handle for the synthesis of enantiomerically pure compounds, crucial for drug efficacy and safety profiles.
• Chemical Biology & Probe Synthesis: Employed in the creation of activity-based probes and molecular tools for studying enzyme function and biological pathways.

Basic Information

Item	Detail
Product Name	Benzyl (R)-3-(Chlorosulfonyl)Pyrrolidine-1-Carboxylate
CAS No.	1134112-00-7
Molecular Formula	C12H14ClNO4S
Molecular Weight	303.76 g/mol
Synonyms	(R)-1-(Benzyloxycarbonyl)-3-(chlorosulfonyl)pyrrolidine; Benzyl (3R)-3-(Chlorosulfonyl)-1-pyrrolidinecarboxylate; (R)-1-CBZ-3-Chlorosulfonylpyrrolidine; (R)-N-CBZ-3-Chlorosulfonylpyrrolidine; 1-Pyrrolidinecarboxylic acid, 3-(chlorosulfonyl)-, phenylmethyl ester, (3R)-; (R)-3-Chlorosulfonyl-1-[(benzyloxy)carbonyl]pyrrolidine
EINECS	Contact for details

Quality Control

Our Benzyl (R)-3-(Chlorosulfonyl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for advanced research and GMP starting material applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and can provide material meeting custom specifications for critical pharmaceutical development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.