Description

Meropenem-D6 is a deuterium-labeled analog of the broad-spectrum carbapenem antibiotic, meropenem, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses, particularly in regulated environments. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise quantification of meropenem in complex matrices such as biological fluids, drug formulations, and environmental samples.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the accurate measurement of meropenem.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking and quantification of meropenem levels in plasma, serum, and other biological tissues during drug development.
• Therapeutic Drug Monitoring (TDM): Supports clinical laboratories in monitoring patient drug concentrations to optimize dosage and ensure therapeutic efficacy while minimizing toxicity.
• Drug Metabolism and Disposition Research: Used in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to understand the fate of meropenem in the body.
• Quality Control and Impurity Profiling: Assists in the analysis of meropenem active pharmaceutical ingredients (APIs) and finished drug products for purity and stability testing.
• Environmental and Residue Analysis: Facilitates the detection and quantification of meropenem residues in environmental samples for ecological impact studies.

Basic Information

Product Name	Meropenem-D6
CAS No.	1133424-00-6
Molecular Formula	C17H19D6N3O5S
Molecular Weight	401.48 g/mol (for labeled form)
Synonyms	Meropenem-d6; (4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid-d6; (-)-(4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid-d6; SM-7338-d6; ICI-194660-d6; Meronem-d6; Merrem-d6
EINECS	Contact for details

Quality Control

Our Meropenem-D6 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is characterized using advanced techniques including NMR, HPLC, and Mass Spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing purity (by HPLC), isotopic purity (D-enrichment), and other critical specifications to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or Certificate of Analysis. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.