Description

Aprepitant-D4 CAS NO 1133387-60-6 is a deuterated internal standard of the antiemetic drug Aprepitant, specifically labeled with four deuterium atoms. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly Liquid Chromatography-Mass Spectrometry (LC-MS/MS). It is a critical tool for pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control units requiring precise pharmacokinetic studies, drug metabolism research, and method validation.

Application

• Quantitative Bioanalysis (LC-MS/MS): Serves as a stable isotope-labeled internal standard for the precise quantification of Aprepitant in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic (PK) and Toxicokinetic (TK) Studies: Enables accurate measurement of drug concentration over time, critical for determining absorption, distribution, metabolism, and excretion (ADME) profiles.
• Drug Metabolism and Disposition Research: Used to study the metabolic pathways and stability of Aprepitant, helping to identify metabolites and understand drug-drug interactions.
• Method Development and Validation: A key component in establishing and validating robust, regulatory-compliant analytical methods for clinical trials and bioequivalence studies.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay verification during the production of Aprepitant and its formulations.
• Forensic and Doping Analysis: Provides a reference standard for confirmatory testing in specialized analytical contexts.

Basic Information

Product Name	Aprepitant-D4
CAS No.	1133387-60-6
Molecular Formula	C23H17D4F7N4O3
Molecular Weight	534.46 g/mol
Synonyms	5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-1,2,3,4-tetrakis(methylene-d) -3H-1,2,4-triazol-3-one; Aprepitant (phenyl-d4); Aprepitant-d4; L-754030-d4; MK-0869-d4; Emend-d4 (deuterated standard)
EINECS	Contact for details

Quality Control

Our Aprepitant-D4 is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch undergoes comprehensive testing, including HPLC for chemical purity, NMR and/or MS for structural confirmation and deuterium incorporation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications for use as an internal standard.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.