Description

[2H7]-Alfuzosin is a deuterium-labeled analog of the α-1 adrenergic receptor antagonist Alfuzosin, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, stable isotope-labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic and metabolic studies, providing a critical tool for researchers and quality control laboratories. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and analytical laboratories engaged in drug development and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise quantification of Alfuzosin and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track and quantify the parent drug, improving data accuracy.
• Bioanalytical Method Development & Validation: Essential for developing and validating robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Clinical and Pre-clinical Research: Supports pharmacokinetic profiling during clinical trials and pre-clinical animal studies to determine drug exposure levels.
• Quality Control in Pharmaceutical Manufacturing: Enables accurate impurity profiling and assay of Alfuzosin in active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Doping Analysis: Can be employed as a reference standard in forensic toxicology and anti-doping control for the detection of Alfuzosin.

Basic Information

Product Name	[2H7]-Alfuzosin
CAS No.	1133386-93-2
Molecular Formula	C19H20D7N5O4
Molecular Weight	~ 392.49 g/mol
Synonyms	Alfuzosin-d7; Deuterated Alfuzosin; Alfuzosin (phenyl-d5, piperazine-d2); N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide-d7; (RS)-N-[3-[(4-Amino-6,7-dimethoxyquinazolin-2-yl)methylamino]propyl]tetrahydrofuran-2-carboxamide-d7
EINECS	Contact for details

Quality Control

Our [2H7]-Alfuzosin is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (deuterium incorporation), and residual solvent content. We adhere to relevant industry standards for reference materials to ensure reliable and reproducible performance in your critical assays.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). For long-term stability, storage at -20°C is recommended. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0% atom D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.