Description

Laropiprant-D4 is a deuterated isotopologue of Laropiprant, a selective prostaglandin D2 receptor antagonist, where four hydrogen atoms are replaced with deuterium. This stable-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based analyses. It is a critical tool for pharmaceutical researchers and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) studies, clinical trial monitoring, and forensic toxicology.

Application

• Primary use as an internal standard for the quantification of Laropiprant in biological matrices (plasma, serum, urine) via LC-MS/MS.
• Enabling precise pharmacokinetic (PK) and bioequivalence studies for pharmaceutical development.
• Supporting drug metabolism research to identify and quantify metabolites.
• Application in clinical trial sample analysis to ensure data integrity and regulatory compliance.
• Use in forensic and anti-doping laboratories for accurate substance confirmation.
• Facilitating method development and validation in analytical chemistry laboratories.

Basic Information

Product Name	Laropiprant-D4
CAS No.	1132664-22-2
Molecular Formula	C21H20D4N2O4
Molecular Weight	372.45 g/mol (approx.)
Synonyms	Laropiprant-d4; MK-0524-d4; 1-{4-[(4-Chlorophenyl)carbonyl]-2,5-dimethyl-1H-pyrrol-1-yl}-3-(trifluoromethyl)-4-([2H4]methylsulfonyl)benzene; (4-((4-Chlorobenzoyl)-2,5-dimethyl-1H-pyrrol-1-yl)-3-(trifluoromethyl)-4-(([2H4]methyl)sulfonyl)benzoic Acid-d4; CR-3041-d4; Prostaglandin D2 Receptor (DP1) Antagonist-d4
EINECS	Contact for details

Quality Control

Our Laropiprant-D4 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical stability. Each batch is characterized by advanced spectroscopic techniques, including NMR and high-resolution mass spectrometry, to confirm deuteration level and structural integrity. Certificates of Analysis (COA) are provided, detailing assay purity (typically ≥98% by HPLC), isotopic enrichment (≥99 atom % D), and absence of interfering impurities, supporting compliance with GLP and GMP guidelines for analytical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % D
Chemical Purity	≤2.0% (Total related substances by HPLC)
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.