Description

Iwr-1-Endo is a potent and selective small molecule inhibitor of the Wnt/β-catenin signaling pathway, a critical regulator of cell proliferation and differentiation. This compound is essential for researchers and developers in the pharmaceutical and biotechnology sectors, providing a valuable tool for studying cancer biology, stem cell regulation, and tissue regeneration. Its high specificity makes it a key candidate for the development of targeted therapies, particularly in oncology and regenerative medicine.

Application

• Pharmaceutical Research & Development: As a lead compound for developing novel anti-cancer therapeutics targeting Wnt-dependent tumors.
• Cancer Biology Studies: Used in vitro and in vivo to investigate the role of the Wnt pathway in tumor initiation, progression, and metastasis.
• Stem Cell Research: A critical reagent for modulating Wnt signaling to control stem cell self-renewal, differentiation, and pluripotency.
• Regenerative Medicine: Applied in research aimed at understanding tissue repair and developing strategies for bone and tissue regeneration.
• High-Throughput Screening (HTS): Serves as a reference standard or positive control in assays designed to discover new Wnt pathway modulators.
• Biochemical & Cellular Assays: Used to validate assay systems and study downstream effects of Wnt/β-catenin signaling inhibition.

Basic Information

Product Name	Iwr-1-Endo
CAS No.	1127442-82-3
Molecular Formula	C19H16N4O3S
Molecular Weight	380.42 g/mol
Synonyms	IWR-1-endo; IWR 1 endo; 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-benzene sulfonamide; 4-[(3aS,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-4,7-methano-2H-isoindol-2-yl]-N-(8-quinolinyl)benzenesulfonamide; Wnt/β-catenin pathway inhibitor IWR-1-endo; IWR-1 (endo-form); Tankyrase inhibitor.
EINECS	Contact for details

Quality Control

Our Iwr-1-Endo is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under dry conditions and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.