Description

Ziprasidone D8 is a deuterated internal standard of the atypical antipsychotic drug ziprasidone, specifically designed for use in quantitative analytical applications. This high-purity compound is essential for ensuring the accuracy and reliability of mass spectrometry-based methods, such as LC-MS/MS, by correcting for variations in sample preparation and instrument response. It is a critical tool for pharmaceutical research and development, clinical laboratories, and forensic toxicology professionals requiring precise drug quantification and metabolite studies.

Application

• Internal Standard for LC-MS/MS analysis of ziprasidone in biological matrices (plasma, serum, urine).
• Quantitative method development and validation in pharmaceutical R&D.
• Pharmacokinetic and bioequivalence studies.
• Forensic and clinical toxicology for accurate drug level determination.
• Metabolite identification and profiling research.
• Quality control and stability testing in pharmaceutical manufacturing.

Basic Information

Product Name	Ziprasidone D8
CAS No.	1126745-58-1
Molecular Formula	C21H13D8ClN4OS
Molecular Weight	416.97 g/mol
Synonyms	5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one-d8; Ziprasidone-d8; Geodon-d8; Zeldox-d8; Deuterated Ziprasidone; Ziprasidone Internal Standard; 6-Chloro-5-(2-(4-(1,2-benzisothiazol-3-yl)piperazin-1-yl)ethyl)-1,3-dihydro-2H-indol-2-one-d8
EINECS	Contact for details

Quality Control

Our Ziprasidone D8 is manufactured under strict quality control protocols to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, chemical purity (by HPLC), isotopic purity (by MS), and residual solvent content. We adhere to cGMP principles for the production of reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.