Description

1-tert-Butyl-3-Bromo-5-Fluorobenzene is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which provides strategic sites for further functionalization, enabling the construction of complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery, material science, and the synthesis of specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated aryl groups.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the tert-butyl and fluorine groups enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers with tailored electronic properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Fluorine Chemistry Studies: A valuable compound for researching the effects of fluorine substitution on aromatic system reactivity and physical properties.

Basic Information

Product Name	1-tert-Butyl-3-Bromo-5-Fluorobenzene
CAS No.	1123172-38-2
Molecular Formula	C10H12BrF
Molecular Weight	231.11 g/mol
Synonyms	3-Bromo-5-fluoro-1-tert-butylbenzene; 1-Bromo-3-tert-butyl-5-fluorobenzene; 5-Bromo-3-fluoro-tert-butylbenzene; tert-Butyl-3-bromo-5-fluorobenzene; 3-Bromo-5-fluoro-tert-butylbenzene; (3-Bromo-5-fluorophenyl)-tert-butane
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl-3-Bromo-5-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our commitment to quality supports applications in cGMP and ISO-compliant research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.