Description

3-Bromo-4-Fluoro-6-Nitrobenzotrifluoride is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique trifluoromethyl and halogen/nitro substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and trifluoromethyl groups enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) due to the reactive bromo substituent, enabling rapid diversification of molecular scaffolds.
• Fluorine Chemistry Research: A valuable compound for studying structure-activity relationships (SAR) and the effects of fluorine substitution in drug discovery and material design.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments where nitro and halogen groups are integral to color and fastness properties.

Basic Information

Product Name	3-Bromo-4-Fluoro-6-Nitrobenzotrifluoride
CAS No.	1121586-27-3
Molecular Formula	C7H2BrF4NO2
Molecular Weight	287.99 g/mol
Synonyms	1-Bromo-2-fluoro-5-nitro-3-(trifluoromethyl)benzene; 2-Bromo-1-fluoro-4-nitro-5-(trifluoromethyl)benzene; 3-Bromo-4-fluoro-6-nitro-α,α,α-trifluorotoluene; Benzene, 1-bromo-2-fluoro-5-nitro-3-(trifluoromethyl)-; 5-Bromo-4-fluoro-2-nitrobenzotrifluoride; 2-Nitro-5-bromo-4-fluorobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluoro-6-Nitrobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing batch-specific results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.