Description

2-Trifluoromethoxy-Ethanesulfonyl Chloride is a specialized organofluorine building block and sulfonylating agent of significant interest in advanced chemical synthesis. Its core value lies in introducing the highly stable trifluoromethoxy (OCF₃) group alongside a reactive sulfonyl chloride moiety, enabling the creation of novel compounds with tailored properties. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent for creating specialty polymers and coatings with unique surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for catalysis and molecular recognition applications.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study protein function and interaction pathways.
• Custom Synthesis and R&D: A critical reagent for contract research organizations (CROs) and academic laboratories exploring new synthetic methodologies.

Basic Information

Product Name	2-Trifluoromethoxy-Ethanesulfonyl Chloride
CAS No.	1118786-91-6
Molecular Formula	C₃H₄ClF₃O₃S
Molecular Weight	212.57 g/mol
Synonyms	2-(Trifluoromethoxy)ethanesulfonyl chloride; 2-(Trifluoromethoxy)ethane-1-sulfonyl chloride; 1-(Trifluoromethoxy)-2-chlorosulfonylethane; Ethanesulfonyl chloride, 2-(trifluoromethoxy)-; OCF3-CH2-CH2-SO2Cl; 2-OCF3-Ethanesulfonyl Chloride; Trifluoromethoxyethylsulfonyl Chloride
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethoxy-Ethanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.