Description

D-Valine-D8 is a high-purity, deuterium-labeled isotopologue of the non-essential amino acid D-valine, identified by CAS NO 1116448-82-8. This stable isotope-labeled compound is critical for applications requiring precise internal standards in mass spectrometry, ensuring accurate quantification and reliable data integrity in complex analytical workflows. It is an essential reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors, particularly for drug metabolism and pharmacokinetic (DMPK) studies, proteomics, and metabolic research.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative internal standard in LC-MS and GC-MS analyses for drug discovery and bioanalytical studies.
• Pharmaceutical Research & Development: Used in the synthesis and metabolic tracing of deuterated drug candidates and in DMPK (Drug Metabolism and Pharmacokinetics) studies.
• Proteomics and Metabolic Research: Enables precise tracking and quantification of amino acid incorporation and turnover in metabolic flux analysis and protein synthesis studies.
• Biochemical Tracing: Acts as a stable isotopic tracer in biochemical pathway analysis and mechanism of action studies.
• Quality Control & Reference Standard: Employed as a certified reference material (CRM) for method validation and quality assurance in analytical laboratories.
• Nutritional Science Research: Used in studies investigating amino acid metabolism, absorption, and utilization.

Basic Information

Product Name	D-Valine-D8
CAS No.	1116448-82-8
Molecular Formula	C5H3D8NO2
Molecular Weight	131.20 g/mol (approx.)
Synonyms	(2R)-2-Amino-3-methyl-2,3,3,4,4,4-d6-butanoic-3,3-d2 acid; (R)-2-Amino-3-methylbutanoic-d8 acid; D-Valine-d8; Deuterated D-Valine; [2,3,3,4,4,4-2H6, 3,3-2H2]-D-Valine; (R)-2-Azaniumyl-3-methyl-4,4,4-trideuterio-3-(trideuteriomethyl)butanoate
EINECS	Contact for details

Quality Control

Our D-Valine-D8 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, meeting the rigorous demands of analytical and research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), and chiral purity. We adhere to relevant industry standards for high-purity fine chemicals, and custom synthesis to specific purity or isotopic enrichment specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.