Description

3,5-Difluoro-4-Iodopyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro-iodopyridine moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Building block for organic electronic materials, such as semiconductors and liquid crystals, where halogenated pyridines tune charge transport properties.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Stille), enabling rapid diversification of the pyridine core.
• Fluorination Chemistry Studies: A valuable substrate for studying nucleophilic aromatic substitution (SNAr) and other fluorination-related mechanistic pathways.

Basic Information

Product Name	3,5-Difluoro-4-Iodopyridine
CAS No.	1116099-07-0
Molecular Formula	C5H2F2IN
Molecular Weight	256.98 g/mol
Synonyms	4-Iodo-3,5-difluoropyridine; 3,5-Difluoro-4-iodopyridine; 4-Iodo-3,5-difluoropyridine; Pyridine, 4-iodo-3,5-difluoro-; 3,5-Difluoro-4-iodo-pyridine
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Iodopyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with all applicable regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.