Description

2-Methoxy-4-Fluorobenzotrifluoride is a high-value fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value proposition lies in the unique combination of methoxy, fluoro, and trifluoromethyl substituents, which enables precise modulation of electronic and steric properties in target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new fluorination methodologies and the effects of fluorine substitution.

Basic Information

Product Name	2-Methoxy-4-Fluorobenzotrifluoride
CAS No.	1114809-20-9
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1-Methoxy-2-fluoro-5-(trifluoromethyl)benzene; 2-Fluoro-4-(trifluoromethyl)anisole; 4-Fluoro-2-methoxybenzotrifluoride; 2-Methoxy-α,α,α,4-tetrafluorotoluene; 2-Methoxy-4-fluorobenzylidene trifluoride; 4-Fluoro-2-methoxy-α,α,α-trifluorotoluene; 2-Fluoro-4-trifluoromethylanisole
EINECS	Contact for details

Quality Control

Our 2-Methoxy-4-Fluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical properties are available upon request and are essential for your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider using an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.35 g/cm³
Refractive Index (n20D)	~1.430

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.