Description

Leucettine L41 is a potent and selective small-molecule inhibitor of the DYRK and CLK families of kinases, with significant research interest. Its core value lies in its ability to modulate key cellular pathways involved in cell cycle regulation and pre-mRNA splicing, making it a critical tool for probing disease mechanisms. This compound is primarily needed by researchers and developers in the fields of academic biochemistry, pharmaceutical R&D, and oncology drug discovery.

Application

• Biochemical Research: A key pharmacological tool for studying the biological functions and signaling pathways of DYRK1A, DYRK1B, and CLK kinases.
• Neurodegenerative Disease Models: Investigated in preclinical research for its potential effects on tau protein phosphorylation, relevant to Alzheimer's disease studies.
• Oncology Research: Used in cell-based assays to explore its role in cell cycle arrest and as a potential lead compound for anticancer therapeutic development.
• Splicing Regulation Studies: Applied in research to understand and modulate alternative pre-mRNA splicing mechanisms controlled by CLK kinases.
• Chemical Probe Development: Serves as a starting point or reference compound for the design and synthesis of novel, more selective kinase inhibitors.
• High-Throughput Screening (HTS): Used as a control or reference compound in kinase inhibitor screening campaigns to validate assay performance.

Basic Information

Product Name	Leucettine L41
CAS No.	1112978-84-3
Molecular Formula	C₁₇H₁₃N₅O₂
Molecular Weight	319.32 g/mol
Synonyms	L41; 1H-Benzimidazol-5-amine, 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(1H-indazol-5-yl)-; 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(1H-indazol-5-yl)-1H-benzimidazol-5-amine; Leucettine-41; DYRK/CLK Inhibitor L41; CLK/DYRK Inhibitor L41
EINECS	Contact for details

Quality Control

Our Leucettine L41 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, NMR, and mass spectrometry. We support research standards and can provide material suitable for in vitro and cell-based assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.