Description

Takinib CAS NO 1111556-37-6 is a potent and selective small-molecule inhibitor of TANK-binding kinase 1 (TBK1). This compound is a critical research tool for investigating the role of TBK1 in cellular signaling pathways, particularly in the context of innate immunity, autophagy, and oncology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and mechanistic studies related to inflammatory diseases and cancer.

Application

• Biochemical Research: Used as a selective TBK1 inhibitor to study kinase function and signaling cascades in cell-based assays.
• Drug Discovery & Development: Serves as a key pharmacological tool and lead compound for developing novel therapeutics targeting TBK1-related pathways.
• Immunology Studies: Employed to elucidate the role of TBK1 in innate immune responses, including interferon production and NF-κB activation.
• Oncology Research: Investigated for its potential to inhibit cancer cell proliferation and survival, particularly in contexts where TBK1 signaling is dysregulated.
• Autophagy Research: Applied in studies exploring the connection between TBK1 activity and the regulation of autophagy.
• Inflammatory Disease Models: Used in preclinical research to validate TBK1 as a therapeutic target for conditions like rheumatoid arthritis and lupus.

Basic Information

Product Name	Takinib
CAS No.	1111556-37-6
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	TAK1 Inhibitor; 5,7-Dihydro-2-(4-morpholinyl)-6-phenylimidazo[1,2-c]pyrido[3,4-e]pyrimidin-6-ium; 6-Phenyl-2-morpholin-4-yl-5,7-dihydroimidazo[1,2-c]pyrido[3,4-e]pyrimidin-6-ium; TBK1 Inhibitor VII; CAS 1111556-37-6
EINECS	Contact for details

Quality Control

Our Takinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural verification, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.