Description

3-Bromo-5-(1,1-Difluoro-Ethyl)-Pyridine is a high-value, halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and difluoroalkyl substituents, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition or receptor modulation.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the difluoroethyl group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and material science applications.
• Organic Electronic Materials: Employed in the research of novel organic semiconductors or charge-transport materials due to its electron-deficient pyridine core and halogen substituents.
• Chemical Biology Probes: Utilized to create tagged molecules or probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Bromo-5-(1,1-Difluoro-Ethyl)-Pyridine
CAS No.	1108724-32-8
Molecular Formula	C7H6BrF2N
Molecular Weight	222.03 g/mol
Synonyms	3-Bromo-5-(1,1-difluoroethyl)pyridine; 5-(1,1-Difluoroethyl)-3-bromopyridine; 3-Bromo-5-(α,α-difluoroethyl)pyridine; Pyridine, 3-bromo-5-(1,1-difluoroethyl)-; 1108724-32-8
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-(1,1-Difluoro-Ethyl)-Pyridine is produced and controlled under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for research and scale-up activities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98-99%)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.