Description

Pac 1-β-D-Glucopyranosiduronic Acid CAS NO 1103440-59-0 is a high-purity, specialized chemical building block derived from glucuronic acid. This compound is critical for advanced research and development in pharmaceutical chemistry, particularly in the synthesis of prodrugs and targeted drug delivery systems. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on creating novel therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of glucuronide prodrugs designed for targeted release and improved bioavailability.
• Bioconjugation Chemistry: Used for attaching therapeutic payloads (e.g., drugs, toxins) to antibodies, peptides, or other targeting molecules via its carboxylic acid group.
• Metabolite Synthesis: Essential for preparing reference standards of drug metabolites for analytical method development and pharmacokinetic studies.
• Enzyme Substrate: Serves as a substrate for β-glucuronidase enzymes in biochemical assays and diagnostic kit development.
• Glycochemistry Research: Employed in the study and synthesis of complex carbohydrates, glycoconjugates, and glycosaminoglycan analogs.
• Polymer Science: Acts as a monomer or modifying agent for creating functionalized, biodegradable polymers with specific degradation profiles.

Basic Information

Item	Details
Product Name	Pac 1-β-D-Glucopyranosiduronic Acid
CAS No.	1103440-59-0
Molecular Formula	C13H14O9
Molecular Weight	314.24 g/mol
Synonyms	1-O-Pac-β-D-Glucopyranosiduronic Acid; 1-O-(4-Acetoxybenzoyl)-β-D-glucopyranuronic Acid; PAC-GlcA; 4-Acetoxybenzoic Acid β-D-Glucopyranosiduronic Acid Ester; 1-(4-Acetoxybenzoyl)-β-D-glucuronic Acid; β-D-Glucopyranosiduronic Acid, 1-(4-acetoxybenzoate); Glucuronic Acid PAC Ester
EINECS	Contact for details

Quality Control

Our Pac 1-β-D-Glucopyranosiduronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. The storage area should be well-ventilated and separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.