Description

4-Chloro-1-Fluoro-2-(2,2,2-Trifluoroethyl)Benzene is a high-value fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both chloro and fluoro substituents alongside a trifluoroethyl side chain, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by manufacturers of specialty materials and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays (LCDs), where it contributes to improved dielectric anisotropy and thermal stability.
• Organic Electronics: Employed in the construction of novel organic semiconductors, charge-transport materials, and electro-optical compounds for OLEDs and photovoltaic cells.
• Specialty Polymer Modifier: Acts as a monomer or additive to impart unique properties like chemical resistance, low surface energy, and enhanced durability to advanced polymers and coatings.
• Chemical Research & Development: A versatile building block in medicinal chemistry, process chemistry, and material science for structure-activity relationship (SAR) studies and scaffold diversification.

Basic Information

Item	Details
Product Name	4-Chloro-1-Fluoro-2-(2,2,2-Trifluoroethyl)Benzene
CAS No.	1099598-24-9
Molecular Formula	C8H5ClF4
Molecular Weight	212.57 g/mol
Synonyms	1-Chloro-4-fluoro-2-(2,2,2-trifluoroethyl)benzene; 2-(2,2,2-Trifluoroethyl)-4-chloro-1-fluorobenzene; 4-Chloro-1-fluoro-2-(trifluoroethyl)benzene; 4-Chloro-α,α,α-trifluoro-o-fluoroethylbenzene; 2-(Trifluoroethyl)-4-chlorofluorobenzene; Benzene, 1-chloro-4-fluoro-2-(2,2,2-trifluoroethyl)-; (4-Chloro-2-fluorophenyl)(trifluoro)methane (incorrect but common misnomer)
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-1-Fluoro-2-(2,2,2-Trifluoroethyl)Benzene is manufactured under strict quality management systems. We employ advanced analytical techniques, including GC, HPLC, and NMR, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical and specialty chemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with each shipment to guarantee traceability and support your regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.