Description

2-Chloro-3-Fluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on a trifluoromethylated benzene ring, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer & Resin Modification: Incorporated into specialty polymers to impart unique properties such as chemical resistance, low surface energy, and enhanced weatherability.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the 2-chloro-3-fluorophenyl motif into more complex structures.
• Dye & Pigment Manufacturing: Employed in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	2-Chloro-3-Fluorobenzotrifluoride
CAS No.	1099597-97-3
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	1-Chloro-2-fluoro-3-(trifluoromethyl)benzene; 2-Chloro-1-fluoro-3-(trifluoromethyl)benzene; 3-Trifluoromethyl-2-chloro-1-fluorobenzene; 2-Chloro-α,α,α-trifluoro-3-fluorotoluene; 2-Chloro-3-fluorobenzyl trifluoride; 2-Chloro-3-fluorophenyl trifluoromethane; (2-Chloro-3-fluorophenyl)trifluoromethane; Benzene, 1-chloro-2-fluoro-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.45 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.