Description

3-Chloro-2-Fluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents on a trifluoromethylated benzene ring, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for the development of new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a precursor in the manufacture of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing biaryl systems common in many functional materials.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new methodologies in selective fluorination and functional group transformations.

Basic Information

Product Name	3-Chloro-2-Fluorobenzotrifluoride
CAS No.	1099597-93-9
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	1-Chloro-2-fluoro-3-(trifluoromethyl)benzene; 2-Fluoro-3-chlorobenzotrifluoride; 3-Chloro-2-fluoro-alpha,alpha,α-trifluorotoluene; 3-Chloro-2-fluoro(trifluoromethyl)benzene; 2-Fluoro-3-chloro-alpha,alpha,α-trifluorotoluene; Benzene, 1-chloro-2-fluoro-3-(trifluoromethyl)-; (3-Chloro-2-fluorophenyl)trifluoromethane
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and fluorides. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.