Description

6-(Trifluoromethyl)Pyridine-2-Carbonyl Chloride is a high-value, reactive organic intermediate characterized by its pyridine core and trifluoromethyl and acid chloride functionalities. This compound matters as a critical building block for synthesizing advanced molecules, where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and binding affinity. It is primarily needed by research chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the creation of functionalized polymers and advanced organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	6-(Trifluoromethyl)Pyridine-2-Carbonyl Chloride
CAS No.	1099597-77-9
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	2-Pyridinecarbonyl chloride, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)picolinoyl chloride; 6-(Trifluoromethyl)-2-pyridinecarbonyl chloride; 2-Carbonyl chloride-6-trifluoromethylpyridine; 6-Trifluoromethyl-2-picolinoyl chloride; Picolinoyl chloride, 6-trifluoromethyl-; 6-Trifluoromethylpicolinic acid chloride
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Pyridine-2-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.