Description

2-Chloro-6-Fluoro-3-Methylbenzotrifluoride is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in its trifluoromethyl and halogen substituents, which are key motifs for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Serves as a key building block for novel herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its ability to influence electronic properties and solubility.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, catalysis studies, and exploring new chemical spaces in fluoroorganic chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	2-Chloro-6-Fluoro-3-Methylbenzotrifluoride
CAS No.	1099597-61-1
Molecular Formula	C9H5ClF4
Molecular Weight	224.58 g/mol
Synonyms	1-Chloro-3-fluoro-2-methyl-5-(trifluoromethyl)benzene; 2-Chloro-6-fluoro-α,α,α-trifluoro-m-xylene; 3-Methyl-2-chloro-6-fluorobenzotrifluoride; 1-Chloro-3-fluoro-2-methyl-5-(trifluoromethyl)benzene; 2-Chloro-6-fluoro-3-methyl-α,α,α-trifluorotoluene; Benzene, 1-chloro-3-fluoro-2-methyl-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Fluoro-3-Methylbenzotrifluoride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.